Academic Publications

  • “The indirect pathway of the basal ganglia promotes negative reinforcement, but not motor suppression” [link] [pdf]
    BR Isett*, KP Nguyen*, JC Schwenk, CN Snyder, KA Adegbesan, U Ziausyte, AH Gittis

    Summary: Here, we examined how downstream pallidal targets of indirect pathway spiny neurons mediate motor and reinforcement. Surprisingly, our results suggest that the indirect pathway plays a more prominent role in negative reinforcement than in motor control.

  • “Distinct kinematic adjustments over multiple timescales accompany locomotor skill development in mice” [link] [pdf]
    KP Nguyen, A Sharma, M Gil-Silva, AH Gittis*, SM Chase*
    Neuroscience 466, 260-272 (2021)

    Summary: We developed a behavioral task to track body and paw kinematics in mice as they learn to stay atop an accelerating wheel. We found that learning was accompanied by stereotypes progressions of paw kinematics that correlated with early, intermediate, and late states of performance.

  • “The 24-h savings of adaptation to novel movement dynamics initially reflects the recall of previous performance” [link] [pdf]
    KP Nguyen, W Zhou, E McKenna, K Colucci-Chang, LC Bray, EA Hosseini, L Alhussein, WM Joiner
    Journal of Neurophysiology 122(3), 933-946 (2019)

    Summary: Here, we trained subjects on a task then asked them to come back the following day. After a 24-hour break, subjects recalled very little of what they learned before despite being given the same instructions and being in the same environment. Astonishingly, after only experiencing a single error like they saw before, we observed near total recall of the learned task.

  • “Why do mice overeat high-fat diets? How high-fat diet alters the regulation of daily caloric intake in mice” [link] [pdf]
    KP Nguyen*,JA Licholai*,WC Fobbs, CJ Schuster, MA Ali, AV Kravitz
    Obesity 26(6), 1026-1033 (2018)

    Summary: High Fat Diet (HFD) did not disrupt the regulation of total daily caloric intake, even when up to 90% of total calories came from the HFD. However, HFDs increased daily caloric intake when provided ad libitum and were readily consumed by mice outside of their normal feeding cycle. Ad libitum HFDs appear to induce overconsumption beyond the mechanisms that regulate daily caloric intake.

  • “The decay of motor adaptation to novel movement dynamics reveals an asymmetry in the stability of motion state-dependent learning” [link] [pdf]
    EA Hosseini, KP Nguyen, WM Joiner
    PLoS Computational Biology 13(5) (2017)

    Summary: Both simulation and behavioral results show that velocity-based learning decays at a slower rate than position-based learning, even when learning is significantly biased towards the latter at the end of training. Collectively, these results suggest that motion-state learning based on movement velocity is more stable than that based on limb position.

  • “Feeding Experimentation Device (FED): A flexible open-source device for measuring feeding behavior” [link] [pdf]
    KP Nguyen, TJ O'Neal, OA Bolonduro, E White, AV Kravitz
    Journal of Neuroscience Methods 267, 108-114 (2016)

    Summary: The Feeding Experimentation Device (FED) is a low-cost, open-source, home cage-compatible feeding system that automatically quantifies feeding with high accuracy and temporal resolution. Learn more about FED and stay up-to-date here!